What if your Bone Graft could actively stimulate Bone Regeneration at a Cellular Level?
Written by: Dr. Sneha Dhanke
In modern dental surgery, passive bone grafts are no longer enough. The future lies in the materials that engage, communicate, and regenerate.
What is Bioactivity and Osteostimulation?
Bone grafts have traditionally been focused on osteoconduction, which provides a scaffold for new bone to grow. But nowadays, material can do more. Much more!
BIOACTIVITY
A bioactive graft forms a chemical bond with native bone. It attracts bone-forming cells and induces the deposition of a natural bone-like apatite layer on its surface, integrating seamlessly with the host tissue.[i], [ii]
OSTEOSTIMULATION
Going beyond structure, osteostimulatory materials actively stimulate osteoblasts, promoting cell differentiation, proliferation, and increased bone matrix production.[iii], [iv]
How Sodium Magnesium Silicate powers Bone Regeneration
An innovation? A 4% addition of sodium magnesium silicate (Na-Mg silicate) to β-tricalcium phosphate (β-TCP) [v],[vi],[vii],[viii]
What this trace element blend does:
- Magnesium (Mg²⁺): Promotes angiogenesis by activating ion-mediated signaling pathways (e.g., PI3K/Akt), and supports osteogenesis. It also plays a role in immunomodulation, shifting the immune environment toward regeneration and accelerating bone defect healing.[ix], [x]
- Sodium (Na⁺): Helps maintain osmotic balance and cellular function; may also raise local pH at the defect site, contributing to potential antibacterial effects.[xi]
- Silicate (Si⁴⁺): Stimulates collagen synthesis, bone mineralization, and osteogenic differentiation; supports the simultaneous formation of ACP (amorphous calcium phosphate) and HCA (hydroxycarbonate apatite), accelerating natural bone matrix development.[xii],[xiii]
Advantages of Na-Mg Silicate Doping:
- Enhances surface reactivity for faster bone-bonding
- Stimulates hydroxycarbonate apatite (HCA) layer formation for improved osseointegration
- Boosts osteoblast proliferation and differentiation
- Encourages angiogenesis, essential for sustained tissue regeneration
- Supports controlled resorption aligned with natural bone remodeling rates
CERASORB® Bioactive: Designed to Interact, not just Support
CERASORB® Bioactive is the result of decades of material science, bringing together the best of biosynthetic bone graft technology with biologically active ionic enhancement.
Product Highlights:
- 99% β-TCP + 4% Na-Mg silicate
- Osteostimulatory & bioactive
- Open, interconnected porosity (micro-, meso- & macropores)
- Complete resorption with vital bone replacement
- 100% synthetic — zero risk of disease transmission
Why Choose CERASORB® Bioactive?
In which Cases should CERASORB® Bioactive be used?
CERASORB® Bioactive should be used for filling, bridging, and reconstruction of bone defects and augmentation of the atrophied alveolar ridge.
[i] Understanding the Bioactivity of Bio Ceramics in Bone Healing. (n.d.). Journal of Biomedical Sciences. Retrieved from https://www.hilarispublisher.com/open-access/understanding-the-bioactivity-of-bio-ceramics-in-bone-healing.pdf
[ii] Kokubo, T., & Takadama, H. (2006). How useful is SBF in predicting in vivo bone bioactivity? Biomaterials, 27(15), 2907–2915. https://doi.org/10.1016/j.biomaterials.2006.01.017
[iii] Wu, C., Zhou, Y., Xu, M., Han, P., Chen, L., Chang, J., Xiao, Y. (2017). Silicate-based bioceramics regulate osteoblast differentiation through a BMP2 signalling pathway. Journal of Materials Chemistry B, 5(35), 7641–7651. https://doi.org/10.1039/C7TB01931A
[iv] Zhou, P., Xia, D., Ni, Z., Ou, T., Wang, Y., Zhang, H., Mao, L., Lin, K., Xu, S., & Liu, J. (2020).
Calcium silicate bioactive ceramics induce osteogenesis through oncostatin M. Bioactive Materials, 6(3), 810–822. https://doi.org/10.1016/j.bioactmat.2020.09.018
[v] Liu, Z., He, X., Chen, S., & Yu, H. (2023). Advances in the use of calcium silicate-based materials in bone tissue engineering. Ceramics International, 49(11), 19355-19363.
[vi] Allan, I., Newman, H., & Wilson, M. (2001). Antibacterial activity of particulate Bioglass® against supra-and subgingival bacteria. Biomaterials, 22(12), 1683-1687.
[vii] Zhang, D., Leppäranta, O., Munukka, E., Ylänen, H., Viljanen, M. K., Eerola, E., … & Hupa, L. (2010). Antibacterial effects and dissolution behavior of six bioactive glasses. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 93(2), 475-483.
[viii] Zhang, X., Chen, Q., & Mao, X. (2019). Magnesium enhances osteogenesis of BMSCs by tuning osteoimmunomodulation. BioMed research international, 2019(1), 7908205.
[ix] Mammoli, F., Castiglioni, S., Parenti, S., Cappadone, C., Farruggia, G., Iotti, S., Davalli, P., Maier, J. A. M., Grande, A., & Frassineti, C. (2019). Magnesium Is a Key Regulator of the Balance between Osteoclast and Osteoblast Differentiation in the Presence of Vitamin D₃. International journal of molecular sciences, 20(2), 385. https://doi.org/10.3390/ijms20020385
[x] Choi S, Kim KJ, Cheon S, Kim EM, Kim YA, Park C, Kim KK. Biochemical activity of magnesium ions on human osteoblast migration. Biochem Biophys Res Commun. 2020 Oct 22;531(4):588-594. doi: 10.1016/j.bbrc.2020.07.057. Epub 2020 Aug 16. PMID: 32814632.
[xi] Khan, T. Z., & Al-Hilal, T. A. (2020). Electrolyte Homeostasis and Imbalance. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK541123/
[xii] Uribe, P., Johansson, A., Jugdaohsingh, R. et al. Soluble silica stimulates osteogenic differentiation and gap junction communication in human dental follicle cells. Sci Rep 10, 9923 (2020). https://doi.org/10.1038/s41598-020-66939-1
[xiii] Yu, Y., Bacsik, Z., & Edén, M. (2018). Contrasting In Vitro Apatite Growth from Bioactive Glass Surfaces with that of Spontaneous Precipitation. Materials (Basel, Switzerland), 11(9), 1690. https://doi.org/10.3390/ma11091690